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Oral glucose tolerance testing revealed that AOD-9604 has no negative impact on carbohydrate metabolism

In these studies, AOD 9604 was generally safe and well tolerated

Nonetheless, this work has identified novel findings that support future studies to determine whether microbiome changes are contingent upon the combination of both NNMTi and LD switch and mediated through direct NNMTi-driven mechanisms or through indirect mechanisms such as weight or fat loss 8,13

Commonly reported issues include mild gastrointestinal discomfort, particularly when starting the compound, and temporary headaches during the adjustment period