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doi: 10.1159/000479439 52 AkihiroKTetsujiNTaisukeNIchinoCKazuyaMKeikoN

GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells

Mitochondrial dysfunction The proposed mechanism of chronic cardiotoxicity is a qualitative and quantitative injury of mitochondrial DNA (via impaired respiratory chain and increased production of ROS)