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AP1 is a complex of several proteins including JUN, which is upregulated in motor neurons derived from SOD1 patients compared to other neurons, providing potential mechanistic insights into the selective degeneration of motor neurons in ALS (Bhinge et al., 2017)
4 Challenges and future directions 4.1 Safety considerations The safety profile of dual or triple receptor agonists targeting GLP-1, GIP, and GCG receptors in the treatment of MASLD and related metabolic disorders warrants careful evaluation
Rare cause of cardiotoxicity
In this study, scRNA-seq approaches were employed to mapping cell metabolic atlases of healthy kidney, non-rejection AKI, non-rejection DSA-, non-rejection DSA+, ABMR, and TCMR
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