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Zepbound is approved for weight loss, while Mounjaro is approved for treating type 2 diabetes
In summary, GLP-1RAs have the potential to inhibit neuroinflammation and promote nerve regeneration through the "Tregs-microglia-neuron/NPCs" axis: (1) GLP-1RAs directly and indirectly inhibit the activation of microglia, promote their M2 polarization, and secrete cytokines such as IL-4, IL-10, TGF - , IL-2 to exert anti-inflammatory effects (100)
Ray et al., 2018), although other studies have failed to find an association and questions remain regarding the causal nature of this association (Asakawa et al., 2024)
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