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However, and despite high hopes that SGLT2-inhibition is beneficial in HFpEF, post-hoc preliminary analyses from the DECLARE-TIMI 58 study suggest that SGLT2 inhibition had no effect on cardiovascular mortality in HFpEF patients although still decreasing the incidence of hospitalisation for heart failure [45]
When mitochondria are functioning normally, they generate minimal oxidative products and the bodys antioxidant defense systems keep them in check
However, recent advancements in novel drug delivery systems are overcoming these limitations
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