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GLP-1 receptors are expressed not only in pancreatic beta cells but also in various tissues including the cardiovascular system, kidneys, and immune cells such as macrophages and lymphocytes

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ACP recommends adding a sodium-glucose cotransporter-2 (SGLT-2) inhibitor or glucagon-like peptide-1 (GLP-1) agonist to metformin and lifestyle interventions in patients with type 2 diabetes and inadequate glycemic control, said organization officials in updating their diabetes treatment guidelines for the first time since 2017

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