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Its not FDA drug approval
10.1126/science.274.5291.1379 18 CuiJ
It slows gastric emptying, reduces glucagon secretion, and promotes satiety through a different mechanism than GLP-1 drugs
Melatonin is synthesized in the pineal gland through the activation of two key enzymes: AANAT (arylalkylamine N-acetyltransferase) pCREB (phosphorylated cAMP response element-binding protein) In rat pinealocytes, Epitalon was shown to upregulate both AANAT and pCREB, suggesting a direct enzymatic stimulation of melatonin biosynthesis [56]
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