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17) revealed no significant change in the PDQ-39 between the treatment group and the placebo group (MD = 1.78

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While MPNST remains a challenging malignancy, several promising advances are underway: MEK Inhibitors in NF1-Associated MPNST Given the dysregulation of the RAS/RAF/MEK pathway in NF1-related tumors, MEK inhibitors like selumetinib have shown efficacy in benign plexiform neurofibromas