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FLOW is a global, multinational, randomised controlled trial conducted across 28 countries, 387 sites, and 3,533 participants

Future studies aiming at identifying global changes in gene regulation in response to prolonged exposure to GLP-1R stimulation can determine with greater detail the remaining players in the herein identified metabolic reprograming process

Physical activity and exercise for weight loss and maintenance in people living with obesity

Dietary considerations may play a supportive role, although these are not proven to prevent gallstones in GLP-1 users: Maintain regular meal patterns rather than severely restricting calories, which helps stimulate regular gallbladder contraction Include moderate amounts of healthy fats in the diet (such as olive oil, nuts, and oily fish) to promote gallbladder emptying Ensure adequate hydration to support bile flow Avoid very low-calorie diets unless under specialist supervision For individuals at particularly high risksuch as those with a history of gallstones, rapid weight loss, or multiple risk factorssome specialists may consider ursodeoxycholic acid (UDCA) prophylaxis