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It works through several mechanisms: Enhances insulin secretion from pancreatic beta cells in a glucose-dependent manner Suppresses glucagon release , reducing hepatic glucose production Slows gastric emptying , which prolongs satiety and reduces appetite Acts on brain appetite centers to decrease food intake and promote weight loss Semaglutide is administered as a once-weekly subcutaneous injection (Ozempic, Wegovy) or as a daily oral tablet (Rybelsus)
Most novel drugs also undergo testing for their effect on the QT interval, as QT prolongation is a marker for potential ventricular fibrillation
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2003/04, Gezondheidsraad, (Dutch National Health Counsel) Den Haag 2003: 130-31 2
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