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Although GLP-1 receptor agonists (GLP-1RAs) were initially developed for the management of diabetes and weight loss, their therapeutic applications have since broadened considerably to encompass a range of cardiovascular, renal, and metabolic disorders [15,16,17]

Along this line, IL-6 knockout mice only display an altered metabolic phenotype when fed a high-fat diet (208)

Sublingual absorption depends on mucosal health, saliva production, technique (how long you hold it, whether you swallow prematurely), and even hydration status

This includes evaluation of body mass index (BMI), weight-related comorbidities (type 2 diabetes, hypertension, dyslipidaemia, obstructive sleep apnoea), contraindications to specific medications, and assessment of previous weight loss attempts