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Peripherally, pancytopenia is most often observed, but only 1-2 of the major cell types (erythrocytes, leukocytes, platelets) may be depressed in some cases
Zinc also promotes assembly of the vacuolar H-ATPase on endolysosomal membranes, lowering luminal pH to enable ligandreceptor dissociation, enzyme activation and endosome maturation
Sikiri P, Seiwerth S, Rucman R, et al
Excessive accumulation of intracellular Fe + triggers a burst of ROS production via the Fenton reaction, which directly attacks polyunsaturated fatty acids, initiating lipid peroxidation
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