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Furthermore, some NGPs release extracellular vesicles and other bioactive metabolites that communicate with immune, epithelial, hepatic, and neural tissues, suggesting that their benefits may arise as much from postbiotic signaling as from mere colonization or competitive exclusion (539)

This is consistent with studies showing that HA can improve the performance of nanoparticle-based drug formulations by extending local retention and reducing systemic absorption [1]