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Negative feedback control of hypothalamic feeding circuits by the taste of food
The negotiations will focus on guaranteed pricing, potential price caps, standardized eligibility, coverage, and access criteria, and a mandatory inclusion of lifestyle support programs
Practical factorssuch as insurance coverage, approved indication (type 2 diabetes vs obesity), drug availability, previous side effects, and co-existing health conditionsusually matter more than subtle mechanistic differences when deciding which medication to use and how aggressively to dose it
Important attitude shift A roundup of expert opinions in the Journal of the American Medical Association (JAMA), has heralded the WHO guidelines as a necessary reframing of obesity from an issue of personal control to a complex disease with strong biological mechanisms
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