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The study did not show a clinically meaningful change in either hormones exposure: ethinyl estradiol exposure (level) was essentially unchanged, and levonorgestrel exposure (level) increased modestly (by less than 20%), in a way that, if anything, would maintain or improve contraceptive effectiveness
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The novel role of cathepsin L for neuropeptide production illustrated by research strategies in chemical biology with protease gene knockout and expression
PMC 7233415
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