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Furthermore, the concentration of GSH and the GSH/GSSG ratio vary between intracellular organelles, and this compartmentalization is actively regulated in the cell 3
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Participants enrolled in the study were eligible for analysis in both the intent-to-treat (ITT) and PP analysis, with the exception of three participants in the L-Carnitine group that had completed the study out of window ( n = 1) or had protocol deviations ( n = 2) which excluded them from the PP analysis
Such flexibility may be critical for localized ATP generation in regions distant from mitochondria, such as axonal growth cones, where glycolytic enzymes have been shown to accumulate [10, 62]
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