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Even assuming 100% absorption (which has never been demonstrated for berberine through a patch), you would need to apply over 100 patches simultaneously to match one day of the studied oral dose
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constructed ZnTA nanoenzymes that release Zn to directly inhibit Caspase-3/9 activation, while simultaneously scavenging ROS and downregulating the Bax/Bcl-2 ratio, thereby dual-blocking apoptotic signals [63]
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