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Very high prolonged doses without medical supervision may stress the kidneys
Yes, you can change the time of day you inject, as the most critical factor is taking the dose on the same day every week
If you are not very B12 deficient or not experiencing fatigue or nerve sensations as one of your symptoms, you may not notice the benefits until after youve had 2-3 injections over several weeks
The Italian National Survey for PraderWilli syndrome: An epidemiologic study
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