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(Clin Transl Med, 2021) in 24 older adults (aged 61-80) found that supplementation with GlyNAC (glycine 100 mg/kg/day + NAC 100 mg/kg/day, approximately 7 g each for a 70 kg person) for 16 weeks corrected glutathione deficiency and improved multiple hallmarks of aging including oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, body composition, exercise capacity, and cognition [10]
Oral semaglutide exhibited a neutral effect on major adverse cardiovascular events (hazard ratio [HR], 0.79
No human efficacy claims are made
Rather than acting as a sedative, it is investigated as a regulatory signal within the neural circuits that govern sleep stage transitions
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