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In addition to the mechanism of the HH signaling pathway itself to promote regeneration, HH signaling can also regulate the process of LR through Hippo/Yap signaling (Swiderska-Syn et al., 2016)
Clin Cosmet Investig Dermatol 10:147153 Arjinpathana N, Asawanonda P (2012) Glutathione as an oral whitening agent: a randomized, double-blind, placebo-controlled study
What has been reported in the available human pilot research is that no significant adverse effects were observed - which is a meaningful data point for safety consideration, even if it does not establish efficacy by clinical standards
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