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In recent years, the potential application of metformin in neurological disorders, including stroke, Parkinsons disease, multiple sclerosis, epilepsy, and central nervous system trauma, has attracted considerable attention [48,49,50,51,52,53]

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This dose has been extensively studied in combination with semaglutide under the investigational name CagriSema, achieving up to 22.7% weight reduction at 68 weeks in phase 3 trials [4]