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Clinically, the ATTAIN Phase 3 program showed that orforglipron at its highest dose delivered a mean weight loss of 12.4% over 72 weeks, slightly less than the WEGOVY pills 13.6% at 64 weeks, but with a broader, more diverse patient population of over 3,000 participants

It has also been proposed that the abundant amount of thin saliva produced by the uvula serves to keep the throat well lubricated

The GLP-1 and GIP receptor agonism produces the appetite suppression, gastric emptying reduction and insulin sensitisation that characterise the incretin receptor agonist class

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