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ApoE knockout mice were divided into early diabetes (dosed from 10 to 22 weeks of age), late diabetes (dosed from 18 to 30 weeks of age), and non-diabetic groups after streptozotocin treatment, and each group received semaglutide, tirzepatide, or saline for 12 weeks

Glucose-dependent insulinotropic polypeptide (GIP): This hormone works alongside GLP-1 to enhance insulin sensitivity and reduce appetite