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For GLP-1R and GIPR, both tirzepatide and MAR709 showed strikingly decreased receptor internalization compared to mono agonist
SR18 exhibited an average hydrodynamic diameter of 4.001 nm with a polydispersity index (PDI) of 0.2289, indicating a relatively uniform and predominantly monomeric population in 1 X PBS, compared to 10 M BSA (hydrodynamic diameter 7.631 nm and PDI 0.1645) as shown in Supplementary Figure S5
Neoplastic cells featured nuclear polymorphisms and evident nucleoli as well ( Figure 3 )
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