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Your clinician will determine whether retatrutide, tirzepatide, or semaglutide is the appropriate starting point based on your history, labs, and what you're trying to achieve

STEP UP trial (NCT05646706)

Co-agonism showed, on murine models, the capability to improve insulin secretion and sensitivity in a weight-dependent and weight-independent manner, probably through its action on nutrient metabolism (49, 50), preventing their accumulation and thus making these organs actively involved in metabolism with an improvement in insulin sensitivity and WL, yielding long-lasting effects