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While a few non-electrophilic, non-covalent TRPA1 activators are reported (e.g., carvacrol) 4 , only one (PF-4840154) is especially potent 22
While generally well-tolerated, each has its own profile that should be discussed with a healthcare provider
The SELECT trial, published in 2023, enrolled 17,604 adults with overweight or obesity and established cardiovascular disease but without diabetes
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