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Cubilin and amnionless are the 2 components of the receptor that B12 binds with when it goes up the distal ileum
The clinical dosage range spans 2.510 mg per subcutaneous injection, titrated over 4 weeks before reaching a maintenance dose of 510 mg, five times weekly
NNMT is expressed most highly in human liver (RPKM 188.3), followed by the appendix (RPKM 69.3) and approximately ten other tissues, with a biased expression pattern
Being cynical, I suspect that the push to put more people on oral tablets is a cost cutting exercise
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