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(The FDA has received more than 700 adverse event reports tied to compounded GLP-1s, but its not clear if the events were caused by the drugs.) The companies also see compounders as a threat to their obesity drug sales, which are estimated to balloon to $100 billion a year by 2030

Lower cash prices do not guarantee insurance coverage, and in some cases, including Medicaid programs, weight-loss-only coverage has narrowed rather than expanded

Meanwhile, Cutler reassured GLP-1 users that pancreatitis is a recognized, but uncommon risk associated with the injections

If side effects are intolerable at a particular dose level, clinicians may recommend maintaining that dose for an additional 4 weeks before escalating, or reducing to the previous dose temporarily