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Clinical trial data provides objective evidence about efficacy (24.2% weight loss at 48 weeks), safety (88.8% completion rate), side effects (peak at weeks 6-8, resolve by week 12 for most), and discontinuation outcomes (70-80% regain over 12-18 months, not immediately)
doi:10.1016/j.jpba.2021.113921 124
The specific sites of action and underlying molecular mechanisms that mediate GLP-1R-induced body weight loss are currently being investigated
P., Solders, S., Nakutin, S., Datko, M
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