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11,12 This model proposes that the RBD-PD subtype follows a body-first trajectory, in which -synuclein pathology originates in the peripheral or enteric nervous system (ENS) and subsequently ascends via the vagus nerve to the brainstem, particularly the locus coeruleus/subcoeruleus complex, which is considered one of the core pathological nuclei involved in RBD

doi: 10.1001/jama.2019.0556 17 BrunoA.PandolfoG.CrucittiM.LorussoS.ZoccaliR

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