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Specifically, research shows that Bifidobacterium adolescentis is a high GABA producer.[ref] Lactobacillus brevis DPC6108 and Lactobacillus rhamnosus are also probiotic strains that produce GABA.[ref][ref] A 2024 double blind placebo controlled trial found that a probiotic formulation of Lactobacillus brevis and Lactiplantibacillus plantarum reduced symptoms of depression and improved mood, but did not affect stress levels

This hormone is released by the gut after we eat and serves both to lower blood sugar (thus its use in type 2 diabetes) and provides a feeling of satisfaction

Source: NEJM 2023 Safety profile: The most common adverse events were gastrointestinal (nausea 58%, diarrhea 39%, vomiting 32% in the 12 mg group)

PubMed: [4] Yanagimoto, A., et al