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[2] The doses used in animal studies were also significantly higher than therapeutic doses used in clinical practice
This route completely bypasses first-pass metabolism in the liver, a major advantage over drugs that are swallowed and processed through the hepatic portal system
2 These rewiring events not only restore proliferative capacity but also reprogram tumor metabolism and immune evasion
[See Clinical Pharmacology.] Concomitant Use with a Sulfonylurea When Januvia is used in combination with a sulfonylurea, a lower dose of sulfonylurea may be required to reduce the risk of hypoglycemia
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