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Endocrinology 152 (8), 31033112
The pipeline continues to expand: Novo Nordisk filed an NDA for CagriSema (semaglutide + cagrilintide) in December 2025, which achieved 22.7% weight loss in the REDEFINE 1 trial, and Eli Lilly reported Phase 3 results for retatrutide , a triple GIP/GLP-1/glucagon agonist that delivered 28.7% weight loss
But they also didn't get thin probably because there are specific cells in the vomit center that do not induce vomiting but are critical to weight loss
Stuck AE, Minder CE, Frey FJ
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