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Although whether alpha-cell GLP-1 production and maturity state directly relate to alpha-cell proliferative state has yet to be established, these studies identify a range of alpha-cell maturity and proliferative capacity within islets and allude to the possibility that alpha-cell GLP-1 production may be inherently involved in this heterogeneity
In the -cells, GIP increases insulin release in a glucose-dependent manner
A higher exposure to estrogen and/or progesterone might increase the risk for thromboembolism, and a lower exposure might result in failure of birth control [41]
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