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The well-documented disconnect between biomarker modulation and clinical outcomes in neurodegenerative diseases illustrated most starkly by the history of anti-amyloid therapies means that statistically significant reductions in p-tau or YKL-40 do not constitute evidence of meaningful clinical benefit

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A 2023 meta-analysis found that NAC improved some metabolic markers in women with PCOS, including fasting glucose.21 More recent research has also explored NAC alongside ovulation-induction treatments, suggesting possible benefits for endocrine and reproductive outcomes.20 While the findings are encouraging, researchers are still working to determine which women are most likely to benefit and how NAC compares with established treatments such as metformin

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