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the original dose-response curve was reported to peak at 1 nM rather than to rise monotonically, which is the signature of a biphasic effect rather than a linear one
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commonly reported issues from anecdotal and preclinical sources include injection-site irritation, fatigue or flu-like symptoms, muscle tightness/cramps, temporary water retention, and theoretical immune reactions to the PEG component
(38830068) Recently, there has been a trend towards using higher maintenance doses, with 1.5 grams q12 being used initially for most patients in status epilepticus
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