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Strengths and Limitations The strengths of this meta-analysis are related to the incorporation of direct evidence from recently published head to head trials, the variety of outcomes assessed, and the investigation of plausible clauses of heterogeneity by sensitivity analyses
It takes a measured baseline and a follow-up test
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However, it would be wise to assess retinopathy status, patients BMI, age and preference for weekly subcutaneous injections or daily oral administrations as well as the dose before starting treatment
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