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Injection site reactions: Wegovy 2.4 mg: 5% (STEP 1) Zepbound 10 mg: 5% (SURMOUNT-1) No meaningful difference
Your appetite drops
True fat regain follows a predictable timeline based on discontinuation studies: 15-20% weight regain in months 1-3, another 20-30% in months 4-9, plateauing around 70-80% total regain by 12-18 months
Importantly, tirzepatide carries a boxed warning for risk of thyroid C-cell tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
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