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Men tend to carry more visceral fat, the deep abdominal fat that wraps around organs and drives a lot of cardiovascular and diabetes risk
It also modulates neuroendocrine function, particularly by normalizing melatonin secretion, thereby influencing circadian rhythm regulation and age-related hormonal balance
Rest days do not produce the same acute IGF-1R expression, so dosing on non-training days achieves systemic IGF elevation without the targeted muscle benefit
The theoretical rationale centers on several observations
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