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Melanin , the pigment responsible for skin coloration, can lead to dark spots and hyperpigmentation when overproduced
Increased expression of DAF-16, the ortholog of human FoxO proteins in the worm Caenorhabditis elegans , due to a mutation of the insulin/IGF-1 receptor daf-2 has been found to significantly increase the worm's lifespan [2, 3]
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By silencing NNMT, it enables a natural uptick in NAD levels, leading to enhanced mitochondrial function, lean mass preservation, and fat metabolism without overstimulation
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