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Semaglutide is a well-known GLP-1 receptor agonist, and tirzepatide also acts on GLP-1 receptors but has an additional benefit of working on GIP receptors, which are another part of how the body manages blood sugar

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Top-line results of the Phase 2 trial demonstrated metopimazine led to a 40% reduction in the incidence of nausea and a 56% reduction in frequency of vomiting