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Because NAD+ is used in hundreds of enzymatic reactions throughout the body, particularly in tissues with high energy demands, replenishing NAD+ levels directly via injection may support a more robust and sustainable cellular response

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Those with kidney or liver impairment should exercise caution, as high-dose nicotinamide has been associated with liver toxicity in some cases

Among them, protein kinase C (PKC), a family of protein kinase enzymes involved in various cellular mechanisms, has been shown to phosphorylate NRF2 at Ser40 in its Neh2 domain, disrupting the association with KEAP1 and promoting its activation [203, 204]