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Medicine 99: e22303
A 2022 study published in JAMA Internal Medicine reported that GLP-1 drugs can impair gallbladder motility, potentially increasing the risk of gallbladder and bile duct diseases, including gallstones
But fasting layered on top of GLP-1 medication creates a compounding problem
This effect was even more pronounced when TPL was combined with cisplatin (DDP), which enhanced anti-tumor responses by decreasing markers of tumor vascularization (CD31) and M2 polarization (CD206), resulting in significant tumor growth inhibition and increased survival in vivo
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