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LipRSV exerted limited and region-dependent redox effects, reducing ROS levels only in the hippocampus, cerebellum, and posterior cortex, while failing to improve behavioral outcomes and being associated with unfavorable neurochemical alterations, including reduced BDNF and NGF levels
These unquenched free radicals then turn inward, attacking the mitochondria themselvesdamaging mitochondrial DNA, essential transport proteins, and inner-membrane lipids like cardiolipin