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Both IDH1 and IDH2 enzymes utilize NADP + as their cofactor and generate NADPH via oxidative decarboxylation of isocitrate outside the context of the TCA cycle

In the self-insured market, the company changed the prior authorization requirements to require that patients participate in a weight loss program and also required that patients have an in-person relationship with their prescriber

Most cases resolve within 13 weeks with increased fluid intake and magnesium supplementation