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Notably, the upregulated metabolites were related primarily to glutathione metabolism, including key precursors for glutathione synthesis ( -glutamylcysteine and acetylcysteine), metabolites involved in glutathione catabolism and its byproducts (cysteinylglycine and Cys-Gly), and both oxidized and reduced forms of glutathione (GSSG and GSH) and glutathione disulfide

Tirzepatide dosing schedule Tirzepatide follows a dose escalation from 2.5 mg to the maximum approved dose of 15 mg, with increases occurring every four weeks

doi: 10.1016/j.neubiorev.2024.105728 123 BlattGJFatemiSH

Patients typically need to receive injections once or twice a week for several months, followed by maintenance injections every few weeks or months for up to five years or longer