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Heart rate increase: semaglutide may modestly increase resting HR
One mouse trial evaluating 15mg/kg three times weekly intraperitoneally showed a modest trend towards increased median and maximum lifespan by 6.4 and 7% respectively.5 Studies on endogenous MOTs-C in humans have found that higher levels of MOTs-C are associated with improved maximal leg press scores in elderly patients, though, the relationship of MOTs-C with aging in men 18 to 81 years of age has not been found to be linear.8 Though preliminary animal data is exciting, there are no current studies in human patients
One small study suggests it may not, but further research is needed before being able to make recommendations based on the information
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