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Name: surmount-1 trial tirzepatide weight loss non-diabetic Gastrointestinal tolerability and reduction associated with in adults with obesity or overweight with and without type 2 diabetes in the SURMOUNT‐1 to ‐4 trials - Rubino - 2025 SURMOUNT‐1 study design. This is
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It has shown the unique ability to preferentially reduce fat mass while preserving (or increasing) lean muscle mass addressing a major limitation of current GLP-1s

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2.1.1 Monoamine transporter disruption and neurotransmitter release METH disrupts the reuptake and enhances the release of dopamine, serotonin, and norepinephrine, significantly increasing their extracellular concentrations