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Presented for research literature review only Rosellini E et al
The strong synergy with PEA makes combination therapy particularly attractive for patients with inadequate response to standard treatments.[7][22] Advantages: Addresses nociplastic pain mechanisms via mGlu2 upregulation
Clinical studies suggest that while most patients observe weight loss as early as 12 to 16 weeks after starting treatment, significant weight loss may take up to 68 weeks
This is one reason the loading schedule is medically supervised rather than something to rush
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