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Peptides administered by injection bypass first-pass metabolism entirely, while intranasal delivery relies on absorption across nasal mucosa and is subject to enzymatic degradation and variable permeability
10.1152/ajpheart.00646.2012 106
The Helsinn clinical program investigating ipamorelin for postoperative ileus (ClinicalTrials.gov identifiers available) used IV administration, which is not directly comparable to subcutaneous research protocols
Some protocols involve longer continuous use for 6-12 months with ongoing monitoring
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